STUDIES ON DIACEREIN BIODEGRADABILITY

Published in Scientific Bulletin. Series F. Biotechnologies, Vol. XVII
Written by Caterina TOMULESCU, Eugenia MOCANU, Misu MOSCOVICI, Gabriela SAVOIU, Maria PETRESCU, Nicoleta DOBRE

Diacerein (DCN) is an anti-inflammatory, non-steroid drug with an analgesic effect, used in the treatment of osteoarthritis. DCN is pharmaceutically formulated as a yellow powder in capsules for oral use and it is mainly obtained from extracts of Rheum Emodi (rhubarb) and Aloe Vera. The pollution with pharmaceutical products represents one of the main interests in environmental protection. The influence of DCN was tested on different strains of bacteria and yeasts, common species that can be found in water and soil, and play an important part in decomposing chemical pollutants. The direct action of the pharmaceutical powder evenly spread or dispersed in solid specific culture media was evaluated. In liquid media in which different DCN concentrations were added, the microbial growth and DCN metabolization were analyzed using spectrophotometric methods. On solid media, DCN ioaccumulated in the microorganism colonies, giving them an orange colour depending on their specificity. In liquid media, DCN had an inhibitory effect or was an enhancer of the pigments colour naturally secreted by some strains of bacteria.

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Tomulescu C., Mocanu E., Moscovici M., Savoiu G., Petrescu M., Dobre N. 2013, STUDIES ON DIACEREIN BIODEGRADABILITY. Scientific Bulletin. Series F. Biotechnologies, Vol. XVII, ISSN 2285-1364, 177-180.


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