ISSN 2285-1364, ISSN CD-ROM 2285-5521, ISSN ONLINE 2285-1372, ISSN-L 2285-1364

IN SILICO APPROACH FOR THE IDENTIFICATION AND CHARACTERISATION OF BIOACTIVE PEPTIDES FROM SILVER CARP COLLAGEN

Published in Scientific Bulletin. Series F. Biotechnologies, Vol. XXVI, Issue 1
Written by Grigore-Mihăiță STAN, Diana CONSTANTINESCU-ARUXANDEI, Dan Florin MIHĂILESCU, Florin OANCEA

The paper aimed to identify in silico bioactive peptides with antioxidant and antihypertensive effects from silver carp collagen. This approach involved the use of a wide range of specialized online databases and tools to identify bioactive peptides from various protein sources. In this case, the collagen type-I alpha-1 protein sequence was extracted from UniProtKB with the identification code A0A077B3P8. The digestion was simulated using the BIOPEP database with the following enzymes: subtilisin, papain and pepsin. ExPASy ProtParam, Peptide Ranker, PepCalc, and ToxinPred showed that silver carp collagen is a significant source of biologically active peptides, health promoters with potential antihypertensive and antioxidant effects. The computational approach used in this study offered useful initial insights for more extensive studies.

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{simplepopup popup="false" name="Citation16"}STAN G.M., CONSTANTINESCU-ARUXANDEI D., MIHAILESCU D.F., OANCEA F. 2022, IN SILICO APPROACH FOR THE IDENTIFICATION AND CHARACTERISATION OF BIOACTIVE PEPTIDES FROM SILVER CARP COLLAGEN. Scientific Bulletin. Series F. Biotechnologies, Vol. XXVI, Issue 1, ISSN 2285-1364, 126-136. {/simplepopup}