Published in Scientific Bulletin. Series F. Biotechnologies, Vol. XXIV
Written by Alice GRIGORE, Svetlana COLCERU-MIHUL, Corina BUBUEANU, Lucia PIRVU, Roxana MATEI, Ionica BAJENARU, Ileana Paraschiv, Cornelia NICHITA
Plants are widely used for the development of new products for cosmetics and pharmaceutical applications. In recent years, it is increasingly recognized that the active properties of plant extracts, which are usually complex mixtures of many components, are not due to the activity of a single component, but is the result of the synergistic effects of the elements of the mixture. The aim of this study was to demonstrate the feasibility of a poly-herbal formulation based on Daucus carota L. and Prunus armeniaca L. to be included in cosmetics as an active ingredient. Three types of extracts were taken into consideration: hydroalcoholic, hydroglycerin and macerate in grapeseed oil. HPLC analysis revealed that the hydroalcoholic extract contains polyphenolcarboxylic acids rather than flavonoids. As regards fatty acids quantified by GC, slight differences between sample and control were recorded. The potential effect of the three extracts on murine fibroblasts was evaluated and the proliferation rate was assesed by MTS test. It was showed that none of the extracts are not exhibiting cytotoxic effects. Except for the maximum concentration tested of the hydroglycerin extract, at which the cell viability was around 50%, most of the samples exceeded the 80% threshold. In the case of the hydroglicerin extract, it was observed a strong stimulating effect on cell proliferation compared to control group. It can be concluded that this poly-herbal combination could be used successfully as cosmetic ingredient for its wound healing and regenerative properties.
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