Published in Scientific Bulletin. Series F. Biotechnologies, Vol. XXVII, Issue 1
Written by Dana MIU, Fawzia SHAAT, Ramona-Daniela PAVALOIU
Senolytics represent a group of substances that can eliminate senescent cells in several aging-related pathologies including Alzheimer's disease, atherosclerosis, and type 2 diabetes, etc. Also, senolytic use has been proposed as a potential adjuvant approach to improve the response to senescence-inducing conventional and targeted cancer therapies. In various studies natural compounds (quercetin, fisetin, piperlongumine and curcumin) have been discovered to be effective senolytic agents. Despite the unequivocal promise of senolytics, some senolytics have low bioavailability. In this review, we summarize and discuss the latest methods to improve the bioavailability of immunomodulatory and/or immunostimulatory senolytic bioactive substances. Therefore, an in-depth discussion on diverse delivery strategies of senolytic agents and latest updates on a novel senotherapeutic research will be provided.
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