Published in Scientific Bulletin. Series F. Biotechnologies, Vol. XXIX, Issue 2
Written by Fawzia SHA’AT, Anton-Liviu PETRICA, Ramona-Daniela PAVALOIU
Leveraging senotherapeutics derived from natural sources is pivotal in advancing senotherapy, offering biocompatible and sustainable solutions to target cellular senescence and mitigate age-related diseases. Nanosystems have emerged as versatile vesicles capable of encapsulating and delivering bioactive agents to senescent cells with high specificity and minimal off-target effects. These nanosystems leverage unique physicochemical properties, such as size, surface charge, and functionalization with targeting ligands, to optimize cellular uptake and therapeutic efficacy. Recent advancements in nanotechnology have facilitated the integration of molecular tools such as senolytics and senomorphics within these carriers, enhancing their ability to selectively clear senescent cells or modulate their secretory phenotype. This review highlights the state-of-the-art in nanosystem development for senotherapeutic applications, addressing their advantages, limitations, scalability, economic aspects, regulatory approval, and long-term effects. This work underscores the transformative potential of nanosystems in senotherapeutic delivery and advocates for continued interdisciplinary collaboration to overcome existing barriers and realize their full therapeutic potential.
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