Published in Scientific Bulletin. Series F. Biotechnologies, Vol. XXIX, Issue 2
Written by Marian TOADER, Nicoleta RADU, Narcisa Elena BĂBEANU, Radu-CristianTOMA, Viviana ROMAN
This study aimed to predict, through applying math models, the cytotoxic effects of marine algae-derived biomaterials. The tested bioproducts included both polysaccharide-rich and gold-functionalized extracts, and the cytotoxicity was evaluated in vitro on HepG2 and Caco-2 cell lines. The results obtained revealed that the bioproduct derived from Chlorella sp., enriched with gold, exhibited the highest cytotoxicity (100%), with an IC50=134.75 µL/mL. The bioproduct containing only polysaccharides showed significantly lower cytotoxicity. Predictions regarding the cytotoxicity of selected bioproducts on HepG2 cells highlighted the enhanced activity of gold-functionalized extracts compared to simple polysaccharides. Among all the tested samples, the polysaccharides derived from Undaria pinnatifida exhibited the strongest cytotoxic effect on the Caco-2 cell line, followed by the extract from Porphyra umbilicalis. In conclusion, the results obtained through mathematical prediction demonstrate the potential of marine-derived sources in developing new bioproducts with antitumor properties.
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