Published in Scientific Bulletin. Series F. Biotechnologies, Vol. XXV, Issue 1
Written by Mircea-Cosmin PRISTAVU, Camelia Filofteia DIGUŢĂ, Ionuţ MORARU, Florentina MATEI
The paper aims to present the review of the recent research on anti-aging effect of bioactive plant compounds studied by the use of Saccharomyces cerevisiae as a model organism. Numerous features, such as the chronological lifespan (CLS) and / or the replicative lifespan (RLS) or the measurement of the yeast telomere length, associated with the aging process have been the targets of many studies around the world. The yeast, S. cerevisiae has emerged as a powerful genetic and chemical screening platform because it combines a fast workflow with experimental facilities and the availability of a wide range of mutants. Given these aspects and the mechanisms of aging between yeast and humans, the testing of candidate anti-aging substances has proven to be very successful in finding potential molecular targets. The mentioned methods are very difficult to apply in humans and therefore the side effects are unpredictable and because of this it is very important to quickly discover biologically active plant compounds that can mimic the antiaging action as close to the truth as possible.
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