Published in Scientific Bulletin. Series F. Biotechnologies, Vol. XXVII, Issue 1
Written by Ramona-Daniela PAVALOIU, Fawzia SHA’AT, Corina BUBUEANU, Paul BARBUTA, Ciprian FODOR, Mariana FODOR
Worlwide, cardiovascular diseases (CVDs) is the leading cause of death, taking an estimated 17.8 million lives each year. CVDs include coronary heart disease, rheumatic heart disease, cerebrovascular disease and other conditions. In order to help the treatment of CVDs, this work aims to develop a food supplement based on liposomes. The market for food supplements is growing rapidly but many active ingredients have low bioavailability, especially when taken in high doses. Therefore, this paper is focused on obtaining and characterisation liposomes containing a combination of two plant extracts of Sambucus ebulus and Lycium barbarum. The preparation of liposomes was done by the technique of hydration of the lipid film. Reduction of particle size and degree of uniformity was ensured by the sonication process of the liposomal solutions. The formulations were characterised in terms of entrappment efficiency, particle size, polydispersity index, stability, and the evaluation of antioxidant activity was assessed by DPPH method.
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